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Home/Non-Surgical Facial Rejuvenation Procedures/DAXXIFY™

Dr. Jess Prischmann is excited to introduce Daxxify, the newest neurotoxin treatment for wrinkles. Daxxify has a unique formulation and is the only FDA-approved long-acting, peptide-powered treatment for frown lines. On average, patients experience results that last for 6 months, with some seeing results for up to 9 months.

What Is Daxxify?

Daxxify is the first-of-its-kind long-acting neuromodulator. Studies have shown similar effects to Botox and Dysport but increased duration of action.1 In some patients, Daxxify took as many as 9 months to fully wear off.

Benefits Of Daxxify

Daxxify offers a number of benefits as a treatment option for frown lines and facial wrinkles:

  • It is a non-surgical and non-invasive long-lasting frown line treatment
  • Results last up to 6-9 months
  • Requires no recovery time
  • Is a quick treatment that can be done in 10 minutes
  • Offers visible effects within a few days

How Does Daxxify Work?

Daxxify is a type of medication called a neuromodulator that works by inhibiting the transmission of nerve impulses to the muscles. When injected into the muscles responsible for causing wrinkles, it relaxes them, leading to a smoother, more youthful appearance.

Similar to Botox and Dysport, Daxxify blocks the release of acetylcholine, which plays a role in muscle contraction. This leads to temporary muscle activity reduction and a reduction in the appearance of wrinkles. What makes Daxxify unique is that it is able to reach the site of action more effectively than Botox and Dysport. This means that more of the active ingredient is able to reach its target.

Daxxify is usually administered through a series of injections. The procedure is generally quick and relatively painless, with effects visible within a few days.

Candidates For Daxxify

If you are experiencing wrinkles caused by muscle contractions such as frown lines between the eyebrows and forehead wrinkles and are looking for a non-surgical treatment option, you may be a good candidate for Daxxify.

During your consultation, you’ll have the opportunity to discuss your medical history and treatment goals with Dr. Prischmann to determine if Daxxify is a suitable treatment option for you.

Daxxify is not recommended for individuals who are pregnant, breastfeeding, have a known allergy to any of the ingredients in the medication, have a skin infection at the injection site, or have a neurological disorder that affects muscle function.

The Daxxify Treatment

Before Your Treatment

Before receiving Daxxify injections, it is important to consult with Dr. Prischmann to discuss your medical history and treatment goals. During your consultation, Dr. Prischmann will determine if you are a good candidate for Daxxify. She will also explain the procedure in detail and answer any questions you may have.

During Your Treatment

Before the injection, Dr. Prischmann will clean the treatment area with an antiseptic solution. She will then administer the Daxxify injections according to your customized treatment plan.

After Your Treatment

After receiving Daxxify injections, you should be able to return to your normal activities immediately. Some people may experience mild side effects such as swelling, redness, pain, or tenderness at the injection site, but these effects usually resolve within a few days.

Recovery After Daxxify Injections

Daxxify injections do not generally require any recovery time, and you should be able to return to your normal activities immediately after the treatment. Some people may experience mild side effects such as swelling, redness, pain, or tenderness at the injection site, but these effects usually resolve within a few days.

Daxxify Results

The results of Daxxify injections typically last for up to 6 months, with some patients experiencing results for up to 9 months. Individual results may vary, and the length of time the results last can depend on various factors such as the severity of the wrinkles, the individual’s metabolism, and the individual’s skin type.

After receiving Daxxify injections, you may notice a temporary reduction in the appearance of wrinkles caused by muscle contractions such as frown lines between the eyebrows and forehead wrinkles. The effects of the treatment should be visible within a few days and may continue to improve over the following week or two.

Individual results may vary and it is important to follow the recommendations of Dr. Prischmann for optimal outcomes.

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FAQs About Daxxify

Do you offer Daxxify?

Yes, Daxxify is now available at our practice.

What is Daxxify used for?

Daxxify is FDA-approved for the treatment of glabellar lines (AKA frown lines or “11’s”). It is currently being studied for other uses. It can be used elsewhere on the face and neck and this is considered “off-label.”

How does Daxxify differ from Botox or Dysport?

Daxxify is formulated so it has a similar amount of active ingredient to Botox (meaning it is NOT a “stronger” product). Daxxify is thought to be a more effective product because it contains something called a proprietary peptide. This peptide makes Daxxify stay at the site of action longer than Botox or Dysport. Because it sticks around longer, it gets into cells more effectively. Because it gets into cells more effectively, it is thought to be more potent.

Is Daxxify safe?

Daxxify is safe and effective in the treatment of frown lines.2 The safety data of Daxxify is similar to that of Botox and Dysport for cosmetic use. When studied for frown lines, the most common side effect was headache (4.6%). Other treatment-related side effects included injection site pain (3.6%), injection site redness (3.0%), and injection site swelling (2.8%).3 One notable side effect was eyelid drooping, which occurred in 1.3% of study subjects.

How is a Daxxify treatment performed?

Daxxify is a series of injections (just like Botox and Dysport).

How much does Daxxify cost?

Daxxify does not allow its providers to publish the exact cost of the treatment. Patients can expect to spend more than a conventional Botox treatment. The yearly cost of Daxxify may be less than Botox or Dysport if Daxxify results in fewer overall treatments.

What does Dr. Prischmann think of Daxxify?

In her early experience, Daxxify seems to give better results in the glabella area compared to Botox or Dysport.


1 Journal of the American Academy of Dermatology. DaxibotulinumtoxinA for Injection has a prolonged duration of response in the treatment of glabellar lines: Pooled data from two multicenter, randomized, double-blind, placebo-controlled, phase 3 studies (SAKURA 1 and SAKURA 2). Available: https://pubmed.ncbi.nlm.nih.gov/31791824/. Accessed January 4, 2023.
2 Dermatologic Surgery. DaxibotulinumtoxinA for Injection for the Treatment of Glabellar Lines: Efficacy Results From SAKURA 3, a Large, Open-Label, Phase 3 Safety Study. Available: https://pubmed.ncbi.nlm.nih.gov/32773446/. Accessed January 4, 2023.
3 Plastic and Reconstructive Surgery. DaxibotulinumtoxinA for Injection for the Treatment of Glabellar Lines: Results from Each of Two Multicenter, Randomized, Double-Blind, Placebo-Controlled, Phase 3 Studies (SAKURA 1 and SAKURA 2). Available: https://pubmed.ncbi.nlm.nih.gov/31609882/. Accessed January 24, 2023.